Phospho-CDCP1 (Tyr734) Antibody
货号：
9050S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9050S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-CDCP1 (Tyr734) Antibody recognizes endogenous levels of CDCP1 protein only when phosphorylated at Tyr734. This antibody also cross-reacts with an unidentified protein of 100 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CDCP1 (CUB domain containing protein, SIMA135) is a putative stem cell marker that has been shown in research studies to be highly expressed in some human cancer cells and in both typical and atypical (cancerous) colons (1). Expression of CDCP1 may be epigenetically regulated, as methylation of promoter CpG sequences results in decreased CDCP1 expression (2). The corresponding CDCP1 gene encodes a glycoprotein that acts as a complex, multidomain transmembrane antigen. Three CUB domains in its extracellular region are possibly involved in cell adhesion or extracellular matrix interaction (1,3). Src-family kinases may phosphorylate CDCP1 at five tyrosine residues within its cytoplasmic domain to provide a potential binding site for SH2 domain-containing proteins (3). CDCP1 is a putative marker for hematopoietic stem cells (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 140 |
参考图片Western blot analysis of extracts from HCT 116 cells, untreated (-) or treated with Cub1 mAb (+), using Phospho-CDCP1 (Tyr734) Antibody (upper) or CDCP1 Antibody #4115 (lower).Western blot检测未处理或经过Cub1 mAb (+)处理的HCT 116细胞提取物，使用的抗体是Phospho-CDCP1 (Tyr734) Antibody (上图) 或 CDCP1 Antibody #4115 (下图)。 |
