Phospho-Catenin δ-1 (Ser320) Antibody
货号：
8016S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 8016S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4).Catenin δ-1 (p120 catenin)蛋白有一个氨基末端卷曲螺旋结构域，接着是一个调节结构域，其含有许多磷酸化位点和一个十个连接的42氨基酸重复序列的中央 Armadillo重复区域。该蛋白羧基末端含有不知道的功能(1)。Catenin δ-1 蛋白在调节细胞与细胞的粘附实现关键角色，因为它调节E-cadherin蛋白在细胞表面周转从而确定可用于细胞与细胞粘附的E-cadherin蛋白水平(2) 。Catenin δ-1蛋白在钙粘蛋白介导的粘附有正性和负性的影响(3)。 Actin 动力学也通过catenin δ-1蛋白调节，其能RhoA、Rac和cdc42蛋白(1)。类似于β-catenin蛋白，catenin δ-1蛋白定位于细胞核，但是这个定位的功能仍不清楚。许多研究认为catenin δ-1蛋白在不同类型的肿瘤细胞中不相关被表达或缺乏，认为catenin δ-1蛋白可能作为肿瘤抑制因子的功能(4)。 |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from A-431 cells, untreated (-) or treated with λ phosphatase (+), using Phospho-Catenin δ-1 (Ser320) Antibody (upper) and Catenin δ-1 Antibody #4989 (lower).使用Phospho-Catenin δ-1 (Ser320) Antibody (上图)和Catenin δ-1 Antibody #4989 (下图)，免疫印迹（Western Blot）分析A-431细胞系Phospho-Catenin δ-1和Catenin δ-1蛋白水平，细胞分为未处理组(-)和λ phosphatase处理组(+)。 |
