Phospho-Catenin δ-1 (Ser252) Antibody
货号：
8477S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 8477S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Catenin δ-1 (Ser252) Antibody recognizes endogenous levels of Catenin δ-1 protein only when phosphorylated at Ser252. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from A-431 cells, untreated or treated with λ phosphatase, using Phospho-Catenin δ-1 (Ser252) Antibody (upper) and Catenin δ-1 Antibody #4989 (lower).未处理或经过λ 磷酸酯酶处理的A-431细胞提取物，使用Phospho-Catenin δ-1 (Ser252)抗体（上）和Catenin δ-1抗体#4989（下）进行western blot分析。 |
