Phospho-CaMKK2 (Ser511) Antibody
货号：
12818S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 12818S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-CaMKK2 (Ser511) Antibody recognizes endogenous levels of CaMKK2 protein only when phosphorylated at Ser511. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) is a member of the CaMK family that contains a central Ser/Thr kinase domain followed by a regulatory domain consisting of overlapping autoinhibitory and CaM-binding regions (1). CaMKK2 can be distinguished from other CaMK family members by the presence of a unique Pro/Arg/Gly-rich insert following the ATP-binding domain (2). CaMKK2 phosphorylates CaMKI at Thr177 and CaMKIV at Thr200 (3). CaMKK2 also phosphorylates AMPKα in response to calcium (4). CaMKK2 has been implicated in long-term memory formation (5) and adipocyte development (6). CaMKK2 is phosphorylated at Ser511 by death-associated protein kinase (DAPK) in a signaling cascade thought to be involved in neuronal death (7). |
| 存放说明 | -20C |
| 计算分子量 | 68 |
参考图片Western blot analysis of extracts from various tissues using Phospho-CaMKK2 (Ser511) Antibody (upper). The phospho-specificity of the antibody was verified by blocking with a phosphopeptide (middle) or nonphosphopeptide (lower). Western blot 检测多种组织提取物，使用的抗体是Phospho-CaMKK2 (Ser511) Antibody 兔多抗（上图）。该磷酸化特异性抗体通过被磷酸多肽（中图）阻断或非磷酸多肽（下图）而验证。 |
