Phospho-CaMKII (Tyr231) Antibody
货号：
3356S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3356S |
| 反应种属 | Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-CaMKII (Tyr231) Antibody detects endogenous levels of CaMKII only when phosphorylated at Tyr231. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling (1,2). CaMKII has catalytic and regulatory domains. The binding of Ca2+/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase (3). The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active (3). The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents this dephosphorylation through its inhibitory effect on PP1 (4).Phospho-CaMKII (Tyr231) Antibody is directed against a previously unpublished CaMKII tyrosine phosphorylation site at Tyr231 that was identified at Cell Signaling Technology (CST) using PhosphoScan®, CSTs MS/MS platform for phosphorylation site discovery. Phosphorylation of CamKII at Tyr231 was observed in extracts isolated from ischemic rat brain. |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion or 15 min ischemia only, using Phospho-CaMKII (Tyr231) Antibody (upper) or CaMKII Antibody (lower). Western blot分析大鼠大脑（15分钟局部缺血后再灌注4小时或仅15分钟局部缺血）提取物，使用的抗体是Phospho-PSD93 (Tyr340)Antibody 兔多抗（上图）或 CaMKII Antibody 兔多抗（下图）。 |
