Phospho-ATF-2 (Thr69/71) Antibody【科瑞奥博】

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Phospho-ATF-2 (Thr69/71) Antibody

货号： 9225S 基本售价： 3980.0 元规格： 100ul

产品信息

概述
货号	9225S
反应种属	Human/Mouse/Rat/Monkey
来源宿主	Rabbit
应用	W/IHC-P
使用方法	WB(1:1000) IHC-P (1:100)

性能
供应商	CST
背景	The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins (1). ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways (2-4). Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71 (2-4). Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4). In addition, mutations at these sites reduce the ability of E1A and Rb to stimulate gene expression via ATF-2 (2).
存放说明	-20C
计算分子量	70

参考图片

Western blot analysis of extracts from 293 cells, untreated or UV-treated (lanes 1 and 2), NIH/3T3 cells, untreated or anisomycin-treated (lanes 3 and 4), and C6 cells, untreated or anisomycin-treated (lanes 5 and 6), using Phospho-ATF-2 (Thr69/71) Antibody.western blot方法检测细胞提取物：未经处理和紫外照射（1、2号条带）的 293 细胞，未处理和茴香霉素处理的（3、4号条带）NIH/3T3 细胞，未处理和茴香霉素处理的（5、6号条带）C6细胞。使用的抗体是Phospho-ATF-2 (Thr69/71) Antibody。

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, showing nuclear localization, using Phospho-ATF-2 (Thr69/71) Antibody.免疫组织化学方法检测石蜡包埋的人乳腺癌组织，显示出细胞核的位置。使用的抗体是Phospho-ATF2 (Thr69/71) Antibody。

Immunohistochemical analysis of paraffin-embedded NIH/3T3 cells, untreated (left) or anisomycin treated (right), using Phospho-ATF-2 (Thr69/71) Antibody.免疫组织化学方法检测石蜡包埋的 NIH/3T3细胞，左侧表示未经处理的细胞，右侧表示经茴香霉素处理的细胞。使用的抗体是Phospho-ATF2 (Thr69/71) Antibody。

Immunohistochemical analysis of paraffin-embedded human lung carcioma, control (left) or lambda phosphatase-treated (right), using Phopsho-ATF2 (Thr69/71) Antibody.免疫组织化学方法检测石蜡包埋的人肺癌组织，左侧是对照组，右侧是用lambda磷酸化后的组织。使用的抗体是Phospho-ATF2 (Thr69/71) Antibody。

Immunohistochemical analysis of paraffin-embedded human colon carcioma using Phospho-ATF2 (Thr69/71) Antibody.免疫组织化学方法检测石蜡包埋的人结肠癌组织，使用的抗体是Phospho-ATF2 (Thr69/71) Antibody。