| 货号 | 2035S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P/IF-IC |
| 目标/特异性 | Cleaved Lamin A (Small Subunit) Antibody detects the small fragment of lamin A (and lamin C) resulting from cleavage at aspartic acid 230 by caspase-6. The antibody does not cross-react with full length lamin A or lamin C. |
| 使用方法 | WB(1:1000) IHC-P (1:100) IF-IC (1:200) |
| 供应商 | CST |
| 背景 | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
Western blot analysis of extracts from HeLa, NIH/3T3 or C6 cells, untreated or staurosporine-treated (1 µM), using Cleaved Lamin A (Small Subunit) Antibody. Western blot 检测HeLa、NIH/3T3或C6 细胞提取物，未处理或staurosporine(星形孢菌素)(1 µM)处理，使用抗体为Cleaved Lamin A (Small Subunit)。 | |
Immunohistochemical analysis of paraffin-embedded human tonsil using Cleaved Lamin A (Small Subunit) Antibody. 免疫组织化学分析石蜡包埋的人扁桃体切片，使用抗体为 Cleaved Lamin A (Small Subunit) Antibody 。 | |
Immunohistochemical analysis using Cleaved Lamin A (Small Subunit) Antibody on SignalSlide® Cleaved Caspase-3 (Asp175) IHC Controls #8104 (Jurkat cell pellets,untreated (left) or etopside treated (right). |
