Acetyl-Stat3 (Lys685) Antibody
货号：
2523S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 2523S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Acetyl-Stat3 (Lys685) Antibody detects transfected Stat3 when acetylated at lysine 685. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8,9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage (10). It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8). |
| 存放说明 | -20C |
| 计算分子量 | 79, 86 |
参考图片Western blot analysis of extracts from HeLa cells transfected with Stat3, CBP or both, using Acetyl-Stat3 (Lys685) Antibody (top) or total Stat3 Antibody #9139.Western免疫印迹。用 Acetyl-Stat3 (Lys685) Antibody (上图) 或 total Stat3 Antibody #9139研究转染了Stat3, CBP 或者两个共转的HeLa细胞的细胞提取液。 |
