| 货号 | 19324S |
| 反应种属 | Human\Moneky |
| 来源宿主 | Rabbit |
| 应用 | WB, IP |
| 目标/特异性 | Arginase-2 Antibody recognizes endogenous levels of total arginase-2 protein. This antibody cross-reacts with arginase-1 protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Arginase-2 is a mitochondrial enzyme catalyzing hydrolysis of L-arginine to L-ornithine and urea (1). Research studies have shown that in acute myeloid leukemia (AML) patients arginase-2 is released from AML blasts to plasma leading to the suppression of T-cell proliferation (2). It was also shown that arginase-2 is required for the immunosuppressive properties of neonatal CD71(+) erythroid cells, which inhibits neonatal host defense against infection (3). In addition, the expression of arginase-2 in dendritic cells is repressed by microRNA-155 during maturation (4). This repression is essential for T-cell activation and response (4). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
| 参考文献 | 1 . Lee, E.J. et al. (2013) Mol Cells 35, 396-401. 2 . Mussai, F. et al. (2013) Blood 122, 749-58. 3 . Elahi, S. et al. (2013) Nature 504, 158-62. 4 . Dunand-Sauthier, I. et al. (2014) J Immunol 193, 1690-700. |
Western blot analysis of extracts from human prostate and various cell lines using Arginase-2 Antibody. | |
Immunoprecipitation of arginase-2 from K-562 cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is Arginase-2 Antibody. Western blot analysis was performed using Arginase-2 Antibody. | |
Western blot analysis of extracts from human prostate and human liver using Arginase-2 Antibody (left) and Arginase-1 (D4E3M™) XP® Rabbit mAb #93668 (right). |
