| 货号 | 24979S |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit |
| 应用 | WB, IP |
| 目标/特异性 | LRRC8A/SWELL1 Antibody recognizes endogenous levels of total LRRC8A protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Leucine-rich repeat containing 8 family member A (LRRC8A) belongs to the leucine-rich repeat family of proteins. It is also named SWELL1. LRRC8A forms a heteromeric complex called the volume regulated anion channel (VRAC) with other family members such as LRRC8B, LRRC8C, LRRC8D, or LRRC8E. VRAC maintains cell volume in response to extracellular or intracellular osmotic changes (1,2). The LRRC8A-containing VRAC complex senses ionic strength and is activated by hypotonic stress (3). LRRC8A is also involved in B cell development. Mutations in the LRRC8A gene causes agammaglobulinemia, which is a primary immunodeficiency characterized by severely low or absent serum antibodies and circulating B-cells (4). |
| 存放说明 | -20C |
| 计算分子量 | 85-105 |
| 参考文献 | 1 . Qiu, Z. et al. (2014) Cell 157, 447-58. 2 . Voss, F.K. et al. (2014) Science 344, 634-8. 3 . Syeda, R. et al. (2016) Cell 164, 499-511. 4 . Sawada, A. et al. (2003) J Clin Invest 112, 1707-13. |
Western blot analysis of extracts from NIH/3T3, C2C12, and A549 cells using LRRC8A/SWELL1 Antibody. | |
Immunoprecipitation of LRRC8A from A549 cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is LRRC8A/SWELL1 Antibody. Western blot analysis was performed using LRRC8A/SWELL1 Antibody. |
