| 货号 | 12271S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | β1-Adrenergic Receptor Antibody recognizes endogenous levels of total human β1-Adrenergic Receptor protein. This antibody does not cross-react with β2-Adrenergic Receptor. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | β1-Adrenergic Receptor (β1AR) is a G protein-coupled receptor (GPCR) involved in the regulation of cardiovascular functions (1). Together with β2AR, β1AR is a major βAR in the heart. β1AR is activated by catecholamines and couples to Gαs protein, activating adenylate cyclase and increasing intracellular cAMP levels (2). Beta-blockers (βAR antagonists), one of the major class of therapeutics in cardiovascular medicine, act mostly by preventing catecholamine binding to β1AR (3). |
| 存放说明 | -20C |
| 计算分子量 | 50-200 |
| 参考文献 | 1 . Brodde, O.E. and Michel, M.C. (1999) Pharmacol Rev 51, 651-90. 2 . Rockman, H.A. et al. (2002) Nature 415, 206-12. 3 . Frishman, W.H. Am J Ther 15, 565-76. |
Western blot analysis of extracts from mouse stomach and human heart using β1-Adrenergic Receptor Antibody. Western blot方法检测小鼠胃组织和人心脏组织提取物，使用的抗体为β1-Adrenergic Receptor Antibody. | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing full-length human β1-Adrenergic Receptor (β1AR; +) or full-length human β2-Adrenergic Receptor (β2AR; +), using β1-Adrenergic Receptor Antibody (upper) or β2-Adrenergic Receptor (D6H2) Rabbit mAb #8513 (lower). Western blot方法检测293T细胞提取物，细胞不转染（-）或用表达人的全长β1-肾上腺素受体 (β1AR; +) 或 人的全长 β2-肾上腺素受体 (β2AR; +)的构建体转染，使用的抗体为β1-Adrenergic Receptor Antibody (上图)或 β2-Adrenergic Receptor (D6H2) Rabbit mAb #8513 (下图). |
