| 货号 | 3553S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Zyxin Antibody recognizes endogenous levels of total zyxin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The zyxin family of proteins includes LIMD1, ajuba, trip6, and zyxin, each of which contains three LIM domains at the carboxy terminus. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex. They shuttle in and out of the nucleus where they may function in transcriptional activation (1). Zyxin is involved in the regulation of mechanical force-induced actin polymerization at focal adhesions (2) and in the regulation of adhesion and migration, possibly through the recruitment of Ena/VASP proteins to focal adhesions (3). Zyxin interacts with and may regulate the function of the tumor suppressor myopodin, which inhibits tumor growth and metastasis (4). Zyxin may be phosphorylated by Akt at Ser142 (5). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
| 参考文献 | 1 . Wang, Y. and Gilmore, T.D. (2003) Biochim Biophys Acta 1593, 115-20. 2 . Hirata, H. et al. (2008) J Cell Sci 121, 2795-804. 3 . Hoffman, L.M. et al. (2006) J Cell Biol 172, 771-82. 4 . Yu, Y.P. and Luo, J.H. (2006) Cancer Res 66, 7414-9. |
Western blot analysis of extracts from various cell lines using Zyxin Antibody.使用Zyxin抗体对多种细胞提取物进行western blot分析。 |
