| 货号 | 2392S |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Wnt5a Antibody detects transfected Wnt5a protein in L cells. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | The Wnt family includes several secreted glycoproteins that play important roles in animal development (1). There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins (2). Wnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathways (3). The canonical Wnt/β-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor family (4). Aberrant activation of Wnt signaling pathways is involved in several types of cancers (5). |
| 存放说明 | -20C |
| 计算分子量 | 45 |
| 参考文献 | 1 . Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-305. 2 . Moon, R.T. et al. (1997) Trends Genet. 13, 157-162. 3 . Kohn, A.D. and Moon, R.T. Cell Calcium 38, 439-46. 4 . Logan, C.Y. and Nusse, R. (2004) Annu Rev Cell Dev Biol 20, 781-810. 5 . Giles, R.H. et al. (2003) Biochim Biophys Acta 1653, 1-24. 6 . Mikels, A.J. and Nusse, R. (2006) PLoS Biol. 4, e115. 7 . Katoh, M. and Katoh, M. (2007) Int. J. Mol. Med. 19, 273-278. 8 . Katoh, M. (2005) Oncol Rep 14, 1583-8. 9 . Weeraratna, A.T. et al. (2002) Cancer Cell 1, 279-288. |
Western blot analysis of total cell extracts from L cells overexpressing mouse Wnt5a cells compared to parental L cells, using Wnt5a Antibody. 使用Wnt5a抗体对过表达小鼠Wnt5a的L细胞和对照组的亲本L细胞全细胞提取物进行western blot分析。 |
