| 货号 | 11831S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | WBP2 Antibody recognizes endogenous levels of total WBP2 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | WW-domain binding protein 2 (WBP2) is an adaptor protein first identified in a screen for proteins that interact with YAP1 (1). WBP2 was subsequently shown to bind other WW domain-containing proteins, including TAZ and NEDD4-like ubiquitin-protein ligases (2-5). There is strong evidence for a conserved functional role for WBP2 in the Hippo kinase tumor suppressor pathway. WBP2 interaction is required for the oncogenic properties of TAZ in breast cancer cells (4) and the growth-promoting properties of the YAP homolog Yorkie in Drosophila (6). In vitro studies have also suggested that WBP2 may act as a transcriptional co-activator of both estrogen and progesterone receptors (7); this interaction was shown to be dependent upon tyrosine phosphorylation of WBP2 by c-Src and c-Yes kinases (8). |
| 存放说明 | -20C |
| 计算分子量 | 32 |
| 参考文献 | 1 . Chen, H.I. and Sudol, M. (1995) Proc Natl Acad Sci U S A 92, 7819-23. 2 . Chen, H.I. et al. (1997) J Biol Chem 272, 17070-7. 3 . McDonald, C.B. et al. (2011) Biochemistry 50, 9616-27. 4 . Chan, S.W. et al. (2011) Oncogene 30, 600-10. 5 . Jolliffe, C.N. et al. (2000) Biochem J 351 Pt 3, 557-65. 6 . Zhang, X. et al. (2011) Cell Death Differ 18, 1346-55. 7 . Dhananjayan, S.C. et al. (2006) Mol Endocrinol 20, 2343-54. 8 . Lim, S.K. et al. (2011) FASEB J 25, 3004-18. |
Western blot analysis of extracts from various cell lines using WBP2 Antibody. 使用WBP2抗体对多种细胞提取物进行western blot分析。 |
