| 货号 | 12331S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | VGLUT1 Antibody recognizes endogenous levels of total VGLUT1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Glutamatergic neurons release glutamate, the most common excitatory neurotransmitter. Their synaptic vesicles are filled with glutamate by vesicular glutamate transporters, VGLUTs (1). VGLUT1, also called SLC17A7 for solute carrier family 17 member 7, was first identified as an inorganic phosphate transporter (2). Despite the absence of homology with neurotransmitter transporters, VGLUT1 was later demonstrated to be a glutamate transporter (1) specific to glutamatergic neurons (3). Closely related to VGLUT1, VGLUT2 and VGLUT3 are also involved in glutamate uptake into synaptic vesicles, but define different neuronal subpopulations (4,5). VGLUT1 and VGLUT2 are the most abundant isoforms. VGLUT1 is expressed in the cortex, hippocampus, and cerebellar cortex, while VGLUT2 is mostly found in the thalamus (6,7), and VGLUT3 is expressed in hair cells of the auditory pathway (8). Research studies have linked VGLUT1 to schizophrenia (9) and depressive disorders (10). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
| 参考文献 | 1 . Bellocchio, E.E. et al. (2000) Science 289, 957-60. 2 . Ni, B. et al. (1996) J Neurochem 66, 2227-38. 3 . Takamori, S. et al. (2000) Nature 407, 189-94. 4 . Fremeau, R.T. et al. (2001) Neuron 31, 247-60. 5 . Fremeau, R.T. et al. (2002) Proc Natl Acad Sci U S A 99, 14488-93. 6 . Herzog, E. et al. (2001) J Neurosci 21, RC181. 7 . Kaneko, T. and Fujiyama, F. (2002) Neurosci Res 42, 243-50. 8 . Seal, R.P. et al. (2008) Neuron 57, 263-75. 9 . Oni-Orisan, A. et al. (2008) Biol Psychiatry 63, 766-75. 10 . Uezato, A. et al. (2009) Bipolar Disord 11, 711-25. |
Western blot analysis of extracts from rat synaptosome, mouse brain, and rat brain tissue using VGLUT1 Antibody. Western blot 检测大鼠突触，小鼠大脑和大鼠大脑组织提取物，使用的抗体是 VGLUT1 Antibody兔多抗。 |
