| 货号 | 2485S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | VEGF Receptor 3 Antibody detects transfected levels of VEGFR-3. This antibody does not cross-react with VEGFR-1 and -2. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain (1). VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis (1,2). Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades (1,3). |
| 存放说明 | -20C |
| 计算分子量 | 195 |
| 参考文献 | 1 . Robinson, C.J. and Stringer, S.E. (2001) J Cell Sci 114, 853-65. 2 . Valtola, R. et al. (1999) Am. J. Pathol. 154, 1381-1390. 3 . Saharinen, P. and Petrova, T.V. (2004) Ann. N.Y. Acad. Sci. 1014, 76-87. |
Western blot analysis of cell lysates from COS cells, either untransfected or overexpressing VEGFR-3, using VEGF Receptor 3 Antibody.用VEGF Receptor 3 Antibody对未经转染的和转染后高表达VEGFR-3 的COS细胞进行免疫印迹检测。 |
