VEGF Receptor 2 Antibody【科瑞奥博】

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VEGF Receptor 2 Antibody

货号： 2472S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	2472S
反应种属	Human/Mouse
来源宿主	Rabbit
应用	W
目标/特异性	VEGF Receptor 2 Antibody detects endogenous levels of VEGF-2 receptors. It does not cross-react with other members of VEGF receptor family .
使用方法	WB(1:1000)

性能
供应商	CST
灵敏度	Transfected Only
背景	Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, Grb2, PI-3 kinase, Nck and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). The phosphorylation of Tyr1212 provides a docking site for Grb2 binding and phospho-Tyr1175 binds with the p85 subunit of PI-3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).
存放说明	-20C
计算分子量	210, 230
参考文献	1 . Meyer, M. et al. (1999) EMBO J 18, 363-74. 2 . Dougher-Vermazen, M. et al. (1994) Biochem Biophys Res Commun 205, 728-38. 3 . Kroll, J. and Waltenberger, J. (1997) J Biol Chem 272, 32521-7. 4 . Takahashi, T. et al. (2001) EMBO J 20, 2768-78. 5 . Holmqvist, K. et al. (2004) J Biol Chem 279, 22267-75. 6 . Karkkainen, M.J. and Petrova, T.V. (2000) Oncogene 19, 5598-605. 7 . Rahimi, N. et al. (2000) J Biol Chem 275, 16986-92. 8 . Claesson-Welsh, L. (2003) Biochem Soc Trans 31, 20-4.

参考图片

Western blot analysis of extracts from PAE cells overexpressing VEGF receptor 1 and chimeric VEGF receptor 2 respectively, using VEGF Receptor 2 Antibody. CKR/PAE cells overexpress chimeric receptors containing M-CSF receptor extracullular domain and VEGF Receptor 2 transmembrane and cytoplasmic domains (7).用VEGF Receptor 2 Antibody分别对过表达VEGF receptor 1 和VEGF receptor 2的PAE细胞进行免疫印迹检测。CKR/PAE 细胞过表达含有M-CSF 受体胞外区以及VEGF Receptor 2 的跨膜区和胞内区(7)。