| 货号 | 2893S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | VEGF Receptor 1 Antibody detects endogenous levels of VEGFR-1. This antibody does not cross-react with VEGFR-2 and -3 nor does it detect the sVEGFR-1 variant. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The vascular endothelial growth factor (VEGF) receptor (VEGFR-1, Flt-1) is a 180 kDa receptor tyrosine kinase belonging to the VEGFR (Flt) family (1-3). The receptor is comprised of seven extracellular Ig-like domains, a single transmembrane region and cytoplasmic tail containing the active kinase domain (1,2). VEGFR-1 plays an important role in endothelial cell function and normal vascular development, as well as in hematopoietic function (2,3). VEGF-A is a high affinity ligand of VEGFR-1. VEGFR-1 also binds VEGF-B and PLGF (2). Ligand binding results in very little VEGFR-1 kinase activation, and VEGFR-1/VEGF-A binding negatively regulates VEGF function by diverting the growth factor from other functional VEGF receptors (3). |
| 存放说明 | -20C |
| 计算分子量 | 180 |
| 参考文献 | 1 . Ferrara, N. et al. (2003) Nat Med 9, 669-76. 2 . Clauss, M. (2000) Semin Thromb Hemost 26, 561-9. 3 . Claesson-Welsh, L. (2003) Biochem Soc Trans 31, 20-4. 4 . Kendall, R.L. et al. (1996) Biochem Biophys Res Commun 226, 324-8. 5 . Shibuya, M. (2006) Angiogenesis 9, 225-30; discussion 231. |
Western blot analysis of extracts from PAE cells transfected with either a mock expression vector or human VEGFR-1, using VEGF Receptor 1 Antibody.用VEGF Receptor 1 Antibody对转染了空载体或人的VEGFR-1的PAE细胞的提取物进行免疫印迹检测。 |
