| 货号 | 9412S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | VDAC2 Antibody recognizes endogenous levels of total VDAC2 protein. Based on the amino acid sequences, this antibody is not expected to cross-react with other VDAC isoforms. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 30 |
| 参考文献 | 1 . Hodge, T. and Colombini, M. (1997) J Membr Biol 157, 271-9. 2 . Shimizu, S. et al. (1999) Nature 399, 483-7. 3 . Zheng, Y. et al. (2004) Oncogene 23, 1239-47. 4 . Craigen, W.J. and Graham, B.H. (2008) J Bioenerg Biomembr 40, 207-12. 5 . Yamamoto, T. et al. (2006) J Proteome Res 5, 3336-44. |
Western blot analysis of extracts from human, mouse, and rat brain using VDAC2 Antibody. 使用VDAC2抗体对来自人、小鼠和大鼠脑组织的提取物进行免疫印迹 Western blot 分析。 |
