| 货号 | 4866S |
| 反应种属 | Human/Mouse/Rat/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | VDAC Antibody detects endogenous levels of total VDAC protein. |
| 使用方法 | WB(1:1000) IHC-P (1:75) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 32 |
| 参考文献 | 1 . Hodge, T. and Colombini, M. (1997) J Membr Biol 157, 271-9. 2 . Shimizu, S. et al. (1999) Nature 399, 483-7. 3 . Zheng, Y. et al. (2004) Oncogene 23, 1239-47. 4 . Craigen, W.J. and Graham, B.H. (2008) J Bioenerg Biomembr 40, 207-12. 5 . Yamamoto, T. et al. (2006) J Proteome Res 5, 3336-44. |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using VDAC Antibody. 免疫组织化学分析石蜡包埋的人乳腺癌切片，使用抗体为VDAC Antibody。 | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using VDAC Antibody. 免疫组织化学分析石蜡包埋的人结肠癌切片，使用抗体为VDAC Antibody。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using VDAC Antibody in the presence of control peptide (left) or antigen-specific peptide (right). 免疫组织化学分析石蜡包埋的人乳腺癌切片，使用对照肽（左）或抗原特异性肽（右），使用抗体为VDAC Antibody。 | |
Western blot analysis of extracts from various cell lines, using VDAC Antibody. Western blot 检测多种细胞系提取物，使用抗体为VDAC Antibody。 | |
Immunohistochemical analysis of paraffin-embedded 4T1 syngeneic mouse tumor using VDAC Antibody. 免疫组织化学分析石蜡包埋的4T1同源小鼠肿瘤，使用抗体为VDAC Antibody。 |
