| 货号 | 2398S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Vav3 Antibody detects endogenous levels of total Vav3 protein. The antibody does not cross-react with endogenous levels of other Vav family members. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
| 参考文献 | 1 . Hornstein, I. et al. (2004) Cell. Signal. 16, 1-11. 2 . Crespo, P. et al. (1997) Nature 385, 169-172. 3 . Han, J. et al. (1997) Mol. Cell. Biol. 17, 1346-1353. |
Western blot analysis of extracts from Jurkat, MCF-7 and HUVEC cells using Vav3 Antibody. 使用Vav3 Antibody，免疫印迹(Western blot)分析Jurkat、MCF-7和HUVEC细胞中Vav3蛋白水平。 |
