| 货号 | 3909S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | UTF1 Antibody detects endogenous levels of total UTF1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Undifferentiated embryonic cell transcription factor 1 (UTF1) is expressed in cells of the inner cell mass and the epiblast (1). Expression is down-regulated with development, although it is maintained in the embryonic germ cells and in the adult gonads (1). Reduced expression in embryonic stem cells (ESCs) is associated with failure to differentiate properly, although self-renewal is unaffected (2). UTF1 is tightly associated with chromatin in mouse and human ESCs and may be involved in maintaining an epigenetic environment necessary for the pluripotent state (2,3). Co-expression of UTF1 with reprogramming factors c-Myc, Oct-4, Sox2 and KLF4, along with siRNA knock-down of p53 increased efficiency of induced pluripotent stem cell generation by 100 fold (4). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
| 参考文献 | 1 . Okuda, A. et al. (1998) EMBO J 17, 2019-32. 2 . van den Boom, V. et al. (2007) J Cell Biol 178, 913-24. 3 . Kooistra, S.M. et al. (2009) Stem Cell Res 2, 211-8. 4 . Zhao, Y. et al. (2008) Cell Stem Cell 3, 475-9. |
Western blot analysis of extracts from rat testes, mouse embryo E6.5 and E8.5, mouse brain and rat brain and using UTF1 Antibody.使用UTF1抗体对大鼠鼠肾，E6.5和E8.5小鼠胚胎，小鼠脑组织和大鼠脑组织提取物进行western blot分析。 |
