| 货号 | 4371S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | UGT Antibody detects endogenous levels of proteins from the UGT1A subfamily. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Glucuronidation is a major pathway that enhances the elimination of lipophilic xenobiotics and endobiotics to more more water soluble compounds for excretion (1,2). The UDP-glucuronosyltransferase (UGT) superfamily catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to a variety of endogenous and exogenous compounds. Over 100 UGT mammalian gene products have been described and have been divided into subfamilies based on sequence identities (3). The UGT1 subfamily consists of a number of gene products resulting from alternative splicing. These UGT products can differ in tissue expression and substrate specificity. Also, marked differences in the individual expression of UGT isoforms can account for differences in drug metabolism. |
| 存放说明 | -20C |
| 计算分子量 | 55-60 |
| 参考文献 | 1 . Wells, P.G. et al. (2004) Drug Metab. Dispos. 32, 281-90. 2 . King, C.D. et al. (2000) Curr. Drug Metab. 1, 143-61. 3 . Mackenzie, P.I. et al. (2005) Pharmacogenet. Genomics 15, 677-85. |
Western blot analysis of extracts from 786-0, COLO201 and C6 cell lines, using UGT Antibody. Wetern blot检测786-0, COLO201和C6提取物，所用抗体为UGT Antibody |
