| 货号 | 6925S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TRXR1 Antibody recognizes endogenous levels of total TRXR1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TRXR1 (thioredoxin reductase 1) is a selenocysteine-containing protein that is involved in redox homeostasis (1-6). Its canonical target is thioredoxin, another redox protein (1). Together, they are involved in many functions such as antioxidant regulation (3-6), cell proliferation (2,3,5), DNA replication (2,3), and transcription (3,5). TRXR1 is also capable of reducing a wide array of cellular proteins (1,3). Selenium deficiency, either by diet modification (2,6) or introduction of methylmercury (4), hinders proper expression and function of TRXR1. It is possible that this effect, which results in a higher oxidative state, is a result of the selenocysteine codon (UGA) being read as a STOP codon in the absence of adequate selenium (4). The functions of TRXR1 in cell proliferation and antioxidant defense make it a potential therapeutic target. |
| 存放说明 | -20C |
| 计算分子量 | 55 |
| 参考文献 | 1 . Turanov, A.A. et al. (2010) Biochem J 430, 285-93. 2 . Gasdaska, P.Y. et al. (1995) FEBS Lett 373, 5-9. 3 . Gromer, S. et al. (2004) Med Res Rev 24, 40-89. 4 . Usuki, F. et al. (2011) J Biol Chem 286, 6641-9. 5 . Pappas, A.C. et al. (2008) Comp Biochem Physiol B Biochem Mol Biol 151, 361-72. 6 . Müller, M. et al. (2010) Genes Nutr 5, 297-307. |
Western blot analysis of extracts from various cell lines using TRXR1 Antibody. Wetern blot检测多种细胞系提取物，所用抗体为TRXR1 Antibody。 |
