| 货号 | 3484S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TRPV3 Antibody detects endogenous levels of total TRPV3 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The transient receptor potential cation channel subfamily V member 3 (TRPV3 or VRL3) is a widely expressed ligand-gated ion channel protein that acts in temperature detection between 22º C and 40º C (1). Related transient receptor proteins (TRP) respond to different temperature ranges; TRPA1 responds to cold temperatures and TRPM1 to cool, while warmer temperatures elicit response from TRPV3 and TRPV4. Noxious heat or painful temperatures correlate with TRPM8 and TRPV1 activity (reviewed in 2). TRPV3 is found in association with TRPV1 (VR1) and is thought to modulate activity of this noxious heat-responsive protein (3). Increased TRPV1 and TRPV3 protein expression is correlated with nervous injury, while reduced expression of both may be see in cases of diabetic skin neuropathy (2). Recent evidence implicates TRPV3 in pruritic dermatitis, or itching associated with eczema and related skin disorders (4). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
| 参考文献 | 1 . Xu, H. et al. (2002) Nature 418, 181-6. 2 . Facer, P. et al. (2007) BMC Neurol 7, 11. 3 . Smith, G.D. et al. (2002) Nature 418, 186-90. 4 . Steinhoff, M. and Bíró, T. (2009) J Invest Dermatol 129, 531-5. |
Western blot analysis of extracts from SH-SY5Y cells and mouse brain using TRPV3 Antibody. 对SH-SY5Y细胞和小鼠脑细胞裂解液使用TRPV3抗体进行Western blot分析。 |
