| 货号 | 12215S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TREX1 Antibody recognizes endogenous levels of total TREX1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TREX1 is a broadly expressed 3’ to 5’ exonuclease that acts on single-stranded DNA (ssDNA) to negatively regulate the interferon-stimulatory DNA (ISD) response (1-4). In humans, there are three TREX1 isoforms generated through alternative splicing with predicted molecular weights of 32, 33, and 39 kDa (2). The transcript for the 33 kDa isoform is the most abundant (2). Mice deficient in TREX1 accumulate intracellular ssDNA, which triggers the ISD response and eventually lethal autoimmunity (3,4). Mutations in TREX1 are associated with autoimmune diseases including Aicardi-Goutieres syndrome and systemic lupus erythematosus (5,6). In addition, TREX1 prevents the cell-intrinsic innate immune response to human immunodeficiency virus (HIV) by digesting excess HIV DNA that would normally trigger induction of type I interferon (7). |
| 存放说明 | -20C |
| 计算分子量 | 33 |
| 参考文献 | 1 . Mazur, D.J. and Perrino, F.W. (1999) J Biol Chem 274, 19655-60. 2 . Mazur, D.J. and Perrino, F.W. (2001) J Biol Chem 276, 14718-27. 3 . Yang, Y.G. et al. (2007) Cell 131, 873-86. 4 . Stetson, D.B. et al. (2008) Cell 134, 587-98. 5 . Crow, Y.J. et al. (2006) Nat Genet 38, 917-20. 6 . Lee-Kirsch, M.A. et al. (2007) Nat Genet 39, 1065-7. 7 . Yan, N. et al. (2010) Nat Immunol 11, 1005-13. |
Western blot analysis of extracts from various cell lines using TREX1 Antibody.Western blot分析来自于不同细胞系的提取物，使用的抗体是TREX1 Antibody。 |
