| 货号 | 8616S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Transketolase Antibody recognizes endogenous levels of total transketolase protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Transketolase (TKT) is a homodimer of the pentose phosphate pathway (PPP) that catalyzes the interketol transfer between ketoses and aldoses (1,2). This enzyme, along with transaldolase, connects the nonoxidative branch of the PPP with glycolysis (1-3). Several regions of TKT are evolutionarily conserved from gram-negative bacteria to mammals (3). There is evidence that hypoxic (4) and non-hypoxic induction of HIF1-α (5) increases the expression of TKT. Because cancer cells rely on TKT in altered cell metabolism for nucleic acid synthesis, work has been done to develop inhibitors of TKT as novel cancer treatments (5-8). |
| 存放说明 | -20C |
| 计算分子量 | 68 |
| 参考文献 | 1 . Mitschke, L. et al. (2010) J Biol Chem 285, 31559-70. 2 . Esakova, O.A. et al. (2005) Life Sci 78, 8-13. 3 . Schenk, G. et al. (1997) J Mol Evol 44, 552-72. 4 . Haseloff, R.F. et al. (2006) Proteomics 6, 1803-9. 5 . Zhao, F. et al. (2010) Oncogene 29, 2962-72. 6 . Thomas, A.A. et al. (2008) Bioorg Med Chem Lett 18, 2206-10. 7 . Thomas, A.A. et al. (2008) Bioorg Med Chem Lett 18, 509-12. 8 . Raïs, B. et al. (1999) FEBS Lett 456, 113-8. |
Western blot analysis of extracts from various cell lines using Transketolase Antibody.对多个细胞系使用Transketolase抗体进行Western blot分析。 |
