| 货号 | 49389S |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | LINGO-1 Antibody recognizes endogenous levels of total LINGO-1 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Leucine-rich repeat and immunoglobulin domain-containing protein (LINGO-1) is a potent negative modulator of neuronal processes including neuronal survival, axonal integrity, oligodendrocyte differentiation, and myelination (1-5). LINGO-1, Nogo receptor (NgR), and p75 neurotrophin receptor (p75NTR), or TNF receptor orphan Y (TROY) form a tripartite receptor complex, which activates RhoA/ROCK signaling and is responsible for the inhibition effect of myelin- associated factors (6,7). LINGO-1 is abundantly expressed in the brain and is implicated in various neurodegenerative disorders such as Essential tremor, multiple sclerosis and Parkinson’s disease (8-11). Recently, LINGO-1 was reported to bind directly to amyloid precursor protein (APP), promoting its degradation through lysosomal proteolysis (12). This research study implicated that Lingo-1 plays a critical role in the pathophysiology of Alzheimers disease. |
| 存放说明 | -20C |
| 计算分子量 | 98 |
| 参考文献 | 1 . Shao, Z. et al. (2005) Neuron 45, 353-9. 2 . Mi, S. et al. (2005) Nat Neurosci 8, 745-51. 3 . Zhang, Z. et al. (2009) J Biol Chem 284, 15717-28. 4 . Jepson, S. et al. (2012) J Biol Chem 287, 22184-95. 5 . Lee, X. et al. (2014) Mol Cell Neurosci 60, 36-42. 6 . Mi, S. et al. (2004) Nat Neurosci 7, 221-8. 7 . Park, J.B. et al. (2005) Neuron 45, 345-51. 8 . Inoue, H. et al. (2007) Proc Natl Acad Sci U S A 104, 14430-5. 9 . Delay, C. et al. (2014) Mov Disord 29, 1637-47. 10 . Oh, J. and Calabresi, P.A. (2013) Lancet Neurol 12, 1115-26. 11 . Andrews, J.L. and Fernandez-Enright, F. (2015) Neurosci Biobehav Rev 56, 97-114. 12 . de Laat, R. et al. (2015) Pathobiol Aging Age Relat Dis 5, 25796. |
Western blot analysis of extracts from rat, mouse, and human brain using LINGO-1 Antibody. |
