| 货号 | 2076S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TMP21 Antibody detects endogenous levels of total TMP21 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TMP21, a type I transmembrane protein, is a member of the p24 cargo protein family, which is highly enriched in the ER, the Golgi and coat protein (COP) I and II transport vesicles (1,2). TMP21 is involved in protein transport and vesicular targeting. In particular, TMP21 influences APP trafficking by stabilizing nascent APP. The absence of TMP21 leads to enhanced maturation and cell surface accumulation of APP (3). In addition, TMP21 is a non-essential component of the γ-secretase complex with the potential to modulate γ-secretase mediated cleavage and Aβ production without having an effect on ε-secretase activity (4). |
| 存放说明 | -20C |
| 计算分子量 | 19 |
| 参考文献 | 1 . Blum, R. et al. (1996) J Biol Chem 271, 17183-9. 2 . Blum, R. et al. (1999) J Cell Sci 112 ( Pt 4), 537-48. 3 . Vetrivel, K.S. et al. (2007) Mol Neurodegener 2, 4. 4 . Chen, F. et al. (2006) Nature 440, 1208-12. |
Western blot analysis of extracts from U87-MG, Neuro2A and CAD cells using TMP21 Antibody. Western blot分析U87-MG、Neuro2A和CAD细胞提取液，使用的抗体是TMP21 Antibody 兔多抗。 |
