| 货号 | 4681S |
| 反应种属 | Human/Mouse/Monkey/D.melanogaster |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TLE1/2/3/4 Antibody detects endogenous levels of TLE1, TLE2, TLE3, and TLE4 proteins. Based on homology it should also recognize TLE1 and TLE2 of Zebra fish, TLE2 of Xenopus, and Groucho of Drosophila. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Transducin-like enhancer of split proteins (TLE1, TLE2, TLE3, TLE4, and TLE6) are mammalian homologs of Drosophila Groucho (1). TLEs contain several WD-repeats implicated in protein-protein interaction (2,3). TLEs are transcriptional co-repressors that bind to many transcription factors such as LEF1, Runx1, Oct-1, hepatocyte nuclear factor 3-β as well as histone H3 (4-7). TLEs are differentially expressed during animal development and may have overlapping as well as distinct functions (8). |
| 存放说明 | -20C |
| 计算分子量 | 78-90 |
| 参考文献 | 1 . Stifani, S. et al. (1992) Nat. Genet. 2, 119-127. 2 . Chen, G. and Courey, A.J. (2000) Gene 249, 1-16. 3 . Jennings, B.H. et al. (2006) Mol. Cell 22, 645-655. 4 . Levanon, D. et al. (1998) Proc. Natl. Acad. Sci. U S A 95, 11590-11595. 5 . Malin, S. et al. (2005) Nucleic Acids Res. 33, 4618-4625. 6 . Wang, J.C. et al. (2000) J. Biol. Chem. 275, 18418-18423. 7 . Palaparti, A. et al. (1997) J. Biol. Chem. 272, 26604-26610. 8 . Gasperowicz, M. and Otto, F. (2005) J. Cell Biochem. 95, 670-687. |
Western blot analysis of cell extracts from various cell types using TLE1/2/3/4 Antibody. |
