| 货号 | 4049S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | THEX1 Antibody detects endogenous levels of total THEX1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | THEX1 (3’hExo) is a 3’ exonuclease that may play a role in the degradation of histone mRNA transcripts (1). A recently identified member of the DEDDh 3 exonuclease family, THEX1 binds the conserved stem-loop structure found at the 3’ end of mRNA in vitro (2). The binding of THEX1 to mRNA requires the presence of a terminal ACCCA sequence and is enhanced by the concurrent binding of stem-loop binding protein (SLBP). Cleavage of histone mRNA by THEX1 exonuclease may help produce the rapid turnover of histone mRNA transcripts associated with the completion of DNA replication (3). Additional evidence suggests that THEX1 may be responsible for excising the remaining few 3’ nucleotides following cleavage by a different enzyme (4). |
| 存放说明 | -20C |
| 计算分子量 | 42 |
| 参考文献 | 1 . Dominski, Z. and Marzluff, W.F. (1999) Gene 239, 1-14. 2 . Dominski, Z. et al. (2003) Mol Cell 12, 295-305. 3 . Yang, X.C. et al. (2006) J Biol Chem 281, 30447-54. 4 . Mullen, T.E. and Marzluff, W.F. (2008) Genes Dev 22, 50-65. |
Western blot analysis of extracts from various cell types using THEX1 Antibody. 使用THEX1 Antibody，Western blot分析不同细胞系中THEX1蛋白水平。 |
