| 货号 | 42713S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | THEM2 Antibody recognizes endogenous levels of total THEM2 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | THEM2 is a homotetrameric fatty acyl–CoA thioesterase (1). THEM2 and PC-TP (phosphatidylcholine transfer protein), both enriched in liver, interact to form a complex (1). Cell membrane-bound phosphatidylcholines bind to PC-TP in the complex (1). The complex in turn inhibits IRS-2 and mTORC1, which leads to the suppression of insulin signaling (1). THEM2 has also been shown to regulate adaptive thermogenesis in mice (2). |
| 存放说明 | -20C |
| 计算分子量 | 15 |
| 参考文献 | 1 . Ersoy, B.A. et al. (2013) Sci Signal 6, ra64. 2 . Kang, H.W. et al. (2013) J Biol Chem 288, 33376-86. |
Western blot analysis of extracts from various cell lines using THEM2 Antibody. | |
Immunoprecipitation of THEM2 from COLO 205 cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is THEM2 Antibody. Western blot analysis was performed using THEM2 Antibody. |
