| 货号 | 11990S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Tensin 2 Antibody recognizes endogenous levels of total Tensin 2 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Tensin 2 belongs to the Tensin family of cytoskeletal proteins that includes Tensin 1-3 and Cten, which couple integrins to the actin cytoskeleton (1). Tensin proteins contain SH2 and phosphotyrosine binding (PTB) domains, which enable interaction with diverse signaling molecules and proteins. Tensin family proteins play important roles in signal transduction, cell proliferation, and motility (2-5). Tensin 2 is localized to focal adhesions of various tissues with highest expression in the heart, kidney, and liver (6,7). Tensin 2 inhibits Akt/PKB signaling via a phosphatase tensin-type domain (8). However, Tensin 2 also mediates thrombopoietin/c-Mpl signaling, which promotes Akt signaling (9). Interaction with Tensin 2 is essential for the tumor suppressor function of Deleted in Cancer 1 (DLC1) (10-12). |
| 存放说明 | -20C |
| 计算分子量 | 145-155 |
| 参考文献 | 1 . Lo, S.H. et al. (1994) Bioessays 16, 817-23. 2 . Lo, S.H. et al. (1994) J Cell Biol 125, 1067-75. 3 . Chen, H. and Lo, S.H. (2003) Biochem J 370, 1039-45. 4 . Katz, M. et al. (2007) Nat Cell Biol 9, 961-9. 5 . Chen, H. et al. (2002) Proc Natl Acad Sci U S A 99, 733-8. 6 . Clark, K. et al. (2010) J Cell Biochem 109, 808-17. 7 . Hafizi, S. et al. (2002) Biochem Biophys Res Commun 299, 793-800. 8 . Hafizi, S. et al. (2005) FASEB J 19, 971-3. 9 . Jung AS et al. (2011) Cell Cycle 10, 1838–44 10 . Chan, L.K. et al. (2009) PLoS One 4, e5572. 11 . Clark, K. et al. (2010) J Cell Biochem 109, 808-17. 12 . Chen, L. et al. (2012) J Biol Chem 287, 26104-14. |
Western blot analysis of extracts from various cell lines using Tensin 2 Antibody.使用Tensin2抗体对多种细胞提取物进行western blot分析。 |
