| 货号 | 4987S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Tec Antibody detects endogenous levels of Tec protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Tec kinase belongs to a structurally related subfamily of protein tyrosine kinases (PTKs) that includes Btk, Itk (also known as Emt or Tsk), Bmx, and Txk (or Rlk) (1). With the exception of Txk, the members of this subfamily possess a long amino-terminal region consisting of a pleckstrin homology (PH) domain and a Tec homology (TH) domain . Because PH domains bind phosphoinositides with high affinity, the Tec family kinases have been proposed to act downstream of phosphatidylinositol 3-kinase (PI3-kinase) in signaling pathways. Binding of the PH domain with phosphoinositides is probably required for targeting of Tec family kinases to the cell membrane (2). Tec kinase is activated in response to many upstream signaling events including antigen receptor, RTK, GPCR, and integrin stimulation (3,4). Activated Tec kinase directly phosphorylates substrates such as PLC-gamma 2 and BRDG1 docking protein (5) and mediates downstream signaling. |
| 存放说明 | -20C |
| 计算分子量 | 58 to 75 |
| 参考文献 | 1 . August, A. et al. (2002) Int. J. Biochem. Cell Biol. 34, 1184-1189. 2 . Pillai, S. and Moran, S.T. (2002) Biochim. Biophys. Acta. 1602, 162-167. 3 . Lewis, C.M. et al. (2001) Curr Opin Immunol 13, 317-25. 4 . Schmidt, U. et al. (2004) Int. Arch. Allergy Immunol. 134, 65-78. 5 . Ohya, K. et al. (1999) Proc Natl Acad Sci U S A 96, 11976-81. |
Western blot analysis of extracts from various cell lines, using Tec Antibody.Western免疫印迹。用Tec Antibody研究各种细胞的细胞提取液。 |
