| 货号 | 13224S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TEAD3 Antibody recognizes endogenous levels of total TEAD3 protein. This antibody does not cross-react with other TEAD family proteins. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The Hippo pathway is an important evolutionarily conserved signaling pathway that controls organ size and tumor suppression by inhibiting cell proliferation and promoting apoptosis (1,2). An integral function of the Hippo pathway is to repress the activity of Yes-associated protein (YAP), a proposed oncogene whose activity is regulated by phosphorylation and subcellular localization (3,4). When the Hippo pathway is turned off, YAP is phosphorylated and translocates to the nucleus where it associates with various transcription factors including members of the transcriptional enhancer factor (TEF) family, also known as the TEA domain (TEAD) family (TEAD1-4) (5,6). Although widely expressed in tissues, the TEAD family proteins have specific tissue and developmental distributions. YAP/TEAD complexes regulate the expression of genes involved in cell proliferation and apoptosis (5). |
| 存放说明 | -20C |
| 计算分子量 | 49 |
| 参考文献 | 1 . Pan, D. (2010) Dev Cell 19, 491-505. 2 . Harvey, K.F. et al. (2003) Cell 114, 457-67. 3 . Zhao, B. et al. (2010) Genes Dev 24, 862-74. 4 . Zhao, B. et al. (2008) Curr Opin Cell Biol 20, 638-46. 5 . Zhao, B. et al. (2008) Genes Dev 22, 1962-71. 6 . Zhao, B. et al. (2007) Genes Dev 21, 2747-61. |
Western blot analysis of extracts from various cell lines and tissues using TEAD3 Antibody. 使用TEAD3抗体对多种细胞提取物进行western blot分析。 | |
