| 货号 | 8441S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TCTP Antibody recognizes endogenous levels of total TCTP protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Translationally controlled tumor protein (TCTP/p23/HRF) is a ubiquitously expressed and highly conserved protein involved in various cellular processes, including a role as a histamine releasing factor in chronic allergic disease (1). TCTP binds tubulin in a cell cycle dependent manner and is associated with the mitotic spindle (2). In addition, TCTP interacts with the actin cytoskeleton to regulate cell shape (3). In mitosis, TCTP is phosphorylated by PLK at Ser46, decreasing microtubule stability (4,5). TCTP interacts with the small GTPase Rheb, possibly acting as a GEF and thus activating the TORC1 pathway, controlling cell growth and proliferation (6,7). TCTP has also been shown to be involved in apoptosis and cell stress (8-11). In cultured cells, reduction of TCTP expression can cause tumor reversion (12). |
| 存放说明 | -20C |
| 计算分子量 | 23 |
| 参考文献 | 1 . MacDonald, S.M. et al. (1995) Science 269, 688-90. 2 . Gachet, Y. et al. (1999) J Cell Sci 112 ( Pt 8), 1257-71. 3 . Bazile, F. et al. (2009) Carcinogenesis 30, 555-65. 4 . Yarm, F.R. (2002) Mol Cell Biol 22, 6209-21. 5 . Dephoure, N. et al. (2008) Proc Natl Acad Sci U S A 105, 10762-7. 6 . Dong, X. et al. (2009) J Biol Chem 284, 23754-64. 7 . Hsu, Y.C. et al. (2007) Nature 445, 785-8. 8 . Susini, L. et al. (2008) Cell Death Differ 15, 1211-20. 9 . Bommer, U.A. et al. (2009) Oncogene [Epub ahead of print]. 10 . Gnanasekar, M. et al. (2009) Biochem Biophys Res Commun 386, 333-7. 11 . Gnanasekar, M. et al. (2009) Int J Oncol 34, 1241-6. 12 . Tuynder, M. et al. (2002) Proc Natl Acad Sci USA 99, 14976-81. |
Western blot analysis of extracts from various cell lines using TCTP Antibody. 使用TCTP Antibody，免疫印迹（Western Blot）分析不同细胞中TCTP蛋白水平。 |
