| 货号 | 4042S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | TCL1 Antibody detects endogenous levels of total TCL1. |
| 使用方法 | WB(1:1000) IHC-P (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TCL1 (T cell leukemia 1), MTCP1 and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development, T cell leukemias, prolymphocytic leukemias and B cell lymphomas (1-3). The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt . Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus (4-6). These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport (7). |
| 存放说明 | -20C |
| 计算分子量 | 14 |
| 参考文献 | 1 . Narducci, M.G. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 11712-11717. 2 . Pekarsky, P. et al. (2001) Oncogene 20, 5638-5643. 3 . Hoyer, K.K. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 14392-14397. 4 . Laine, J. et al. (2000) . Mol. Cell 6, 395-407. 5 . Laine, J. et al. (2002) J. Biol. Chem. 277, 3743-3751. 6 . KŸnstle, G. et al. (2002) Mol. Cell. Biol. 22, 1513-1525. 7 . Petock, J.M. et al. (2002) Scientific World Journal 2, 1876-1884. |
Western blot analysis of extracts from Daudi and Ramos cells using TCL1 Antibody. Western blot 分析Daudi 和Ramos 细胞的提取物，使用的抗体为TCL1 Antibody。 | |
Immunohistochemical analysis of paraffin-embedded human tonsil using TCL1 Antibody, low magnification (upper) and high magnification (lower). 免疫组化分析石蜡包埋的扁桃体，上图为低分辨率，下图为高分辨率，使用的抗体为TCL1 Antibody。 |
