| 货号 | 2141S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TANK Antibody detects endogenous levels of total TANK protein. It does not cross react with other TRAF family members. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the TRAF family share a common carboxy-terminal "TRAF domain" which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII) (4). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses. |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Arch, R.H. et al. (1998) Genes Dev 12, 2821-30. 2 . Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88. 3 . Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91. 4 . Rothe, M. et al. (1994) Cell 78, 681-92. 5 . Pomerantz, J.L. and Baltimore, D. (1999) EMBO J 18, 6694-704. 6 . Cheng, G. and Baltimore, D. (1996) Genes Dev. 10, 963-973. 7 . Rothe, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 8241-8846. 8 . Chariot, A. et al. (2002) J. Biol. Chem. 277, 37029-37036. 9 . Chin, A.I. et al. (1999) Mol. Cell. Biol. 19, 6665-6672. 10 . Bonif, M. et al. (2006) Biochem. J. 394, 593-603. |
Western blot analysis of extracts from ACHN (human), PC-12 (rat) and A20 (mouse), using TANK Antibody. Western blot 检测ACHN（人）、PC-12（大鼠）和 A20（小鼠）细胞提取物，使用抗体为TANK Antibody。 |
