| 货号 | 12831S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TAL1 Antibody recognizes transfected levels of total TAL1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings (1). The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding (1). TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells (2), and is required for maturation of erythroid and megakaryocytic lineages in the adult (3). TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1 (4). Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL) (5,6). TAL1 activity is essential for both hematopoiesis and neurogenesis (7). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Massari, M.E. and Murre, C. (2000) Mol Cell Biol 20, 429-40. 2 . Gering, M. et al. (1998) EMBO J 17, 4029-45. 3 . Hall, M.A. et al. (2003) Proc Natl Acad Sci U S A 100, 992-7. 4 . Wadman, I.A. et al. (1997) EMBO J 16, 3145-57. 5 . Lécuyer, E. and Hoang, T. (2004) Exp Hematol 32, 11-24. 6 . Rabbitts, T.H. (1998) Genes Dev 12, 2651-7. 7 . Bradley, C.K. et al. (2006) Eur J Neurosci 23, 1677-89. |
Western blot analysis of 293 cell extracts, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human TAL1 (hTAL1-Myc/DDK; +), using TAL1 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).Western blot分析293T细胞提取物，对照转染(-)或用Myc/DDK标记的全长的人TAL1 (hTAL1-Myc/DDK; +)转染，使用的抗体是：TAL1 Antibody（上图）、β-Actin (D6A8) Rabbit mAb #8457（下图）。 |
