| 货号 | 12236S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Syndecan 4 Antibody recognizes endogenous levels of total Syndecan 4 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Syndecans are a family of type 1 transmembrane heparan sulphate proteoglycans comprising 4 members in mammals (SDC-1 to -4) (1) encoded by four syndecan genes. Syndecans are involved in embryonic development, tumorigenesis, and angiogenesis (2). The extracellular domain harbors attachment sites for heparan sulfate and chondroitin sulfate chains, facilitating interaction with an array of proteins including a plethora of growth factors. In addition, the hydrophobic C-terminal intracellular domain can interact with proteins containing a PDZ domain (2). These interactions place syndecans as important integrators of membrane signaling (3). Syndecans undergo proteolytic cleavage causing the release of their extracellular domain (shedding), converting the membrane-bound proteins into soluble molecular effectors (4). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
| 参考文献 | 1 . Couchman, J.R. (2003) Nat Rev Mol Cell Biol 4, 926-37. 2 . Multhaupt, H.A. et al. (2009) J Physiol Pharmacol 60 Suppl 4, 31-8. 3 . Zimmermann, P. and David, G. (1999) FASEB J 13 Suppl, S91-S100. 4 . Manon-Jensen, T. et al. (2010) FEBS J 277, 3876-89. 5 . Woods, A. and Couchman, J.R. (1994) Mol Biol Cell 5, 183-92. 6 . Harrington, E.O. et al. (1997) J Biol Chem 272, 7390-7. 7 . Oh, E.S. et al. (1997) J Biol Chem 272, 8133-6. 8 . Woods, A. and Couchman, J.R. (1992) J Cell Sci 101 ( Pt 2), 277-90. 9 . Longley, R.L. et al. (1999) J Cell Sci 112 ( Pt 20), 3421-31. 10 . Woods, A. et al. (2000) Arch Biochem Biophys 374, 66-72. 11 . Bishop, A.L. and Hall, A. (2000) Biochem J 348 Pt 2, 241-55. 12 . Keller-Pinter, A. et al. (2010) Cell Mol Life Sci 67, 1881-94. |
Western blot analysis of extracts from Jurkat and HaCaT cells using Syndecan 4 Antibody.Western blot检测 Jurkat和HaCaT细胞提取物。 |
