| 货号 | 4329S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Synaptophysin Antibody detects endogenous levels of total synaptophysin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). |
| 存放说明 | -20C |
| 计算分子量 | 38 |
| 参考文献 | 1 . Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. 2 . Valtorta, F. et al. (2004) Bioessays 26, 445-53. 3 . Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. 4 . Bonanomi, D. et al. (2007) Biochem J 404, 525-34. |
Western blot analysis of extracts from rat brain, mouse brain and human cerebellum using Synaptophysin Antibody. Western blot分析大鼠大脑、小鼠大脑和人小脑提取物，使用的抗体是Synaptophysin Antibody 兔多抗。 |
