| 货号 | 19271S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ST14/Matriptase Antibody recognizes endogenous levels of total ST14/Matriptase protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Suppressor of tumorigenicity 14 protein (ST14), also known as matriptase, is a type II transmembrane protease (1,2). It is highly expressed in epithelia cells and important for the differentiation and homeostasis of epithelium (3). ST14 is synthesized as a single-chain precursor, and cleaved first at Gly149 in endoplasmic reticulum or Golgi. The resulting N-terminal and C-terminal fragments are non-covalently associated, and interact with hepatocyte growth factor activator inhibitor 1 (HAI-1), which facilitates the transportation of ST14 to the plasma membrane. Cell surface ST14 can be activated by autocleavage at Arg614 though an incompletely understood mechanism. HAI-1 inhibits activated ST14, and HAI-1 and ST14 complex can be shed from cell surface (4,5). In different context, ST14 has been reported either as a tumor suppressor or as a tumor promoter (6-8) |
| 存放说明 | -20C |
| 计算分子量 | 80, 95 |
| 参考文献 | 1 . Kim, M.G. et al. (1999) Immunogenetics 49, 420-8. 2 . Lin, C.Y. et al. (1999) J Biol Chem 274, 18231-6. 3 . Oberst, M.D. et al. (2003) J Histochem Cytochem 51, 1017-25. 4 . List, K. et al. Mol Med 12, 1-7. 5 . Bugge, T.H. et al. (2007) Front Biosci 12, 5060-70. 6 . Kosa, P. et al. (2012) Oncogene 31, 3679-95. 7 . Sales, K.U. et al. (2015) Oncogene 34, 4664-72. 8 . Ko, C.J. et al. (2015) Cancer Res 75, 2949-60. |
Western blot analysis of extracts from HCT 116, ZR-75-1, and DLD-1 cells using ST14/Matriptase Antibody. |
