| 货号 | 11830S |
| 反应种属 | Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3). |
| 存放说明 | -20C |
| 计算分子量 | 40, 80 |
| 参考文献 | 1 . Patel, Y.C. (1999) Front Neuroendocrinol 20, 157-98. 2 . Tulipano, G. and Schulz, S. (2007) Eur J Endocrinol 156 Suppl 1, S3-11. 3 . Hofland, L.J. and Lamberts, S.W. (2003) Endocr Rev 24, 28-47. |
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct expressing human SSTR1 (hSSTR1; +), using SSTR1 Antibody. Multiple bands are thought to be GPCR dimers and/or oligomers (Rozenfeld, R. and Devi, L.A. (2010) Handbook of Cell Signaling, 2nd edition, 185-94). Smearing is thought to be due to the addition of N-linked glycosylations at specific NXS/T motifs (Dong, C. et al. (2007) Biochem Biophys Acta 1768, 853-70). Western blot方法检测COS-7细胞提取物：空质粒转染（-）或全长人SSTR1 (hSSTR1; +)质粒转染；使用的抗体是SSTR1 Antibody兔多抗。多个条带应该是G蛋白偶联受体的二聚体和/或低聚物(Rozenfeld, R. and Devi, L.A. (2010) Handbook of Cell Signaling, 2nd edition, 185-94)，拖尾是由于添加在特定的NXS/ T基序的N-连接糖基化(Dong, C. et al. (2007) Biochem Biophys Acta 1768, 853-70)。 | |
Western blot analysis of extract from PC-12 cells using SSTR1 Antibody. Western blot 检测 PC-12 细胞提取物，使用的抗体是SSTR1 Antibody兔多抗。 |
