| 货号 | 13520S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Spartin Antibody recognizes endogenous levels of total spartin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Spastic paraplegia 20 (spartin) is encoded by the SPG20 gene in humans, which is altered in some individuals with an autosomal recessive form of hereditary spastic paraplegia known as Troyer syndrome (1,2). While Troyer syndrome research studies have yet to clearly describe the subcellular localization or function of spartin, additional work implicates spartin in endosomal trafficking, microtubule dynamics, and lipid homoeostasis (3-5). This multifunctional protein is ubiquitously expressed within the nervous system and in non-neuronal tissues, and displays a diverse pattern of cellular localization (6). The SPG20 gene promoter is hypermethylated in many cases of colorectal cancer, which results in decreased spartin expression and cytokinesis arrest. This suggests that spartin expression and methylation state could be a promising biomarker for colorectal tumors (7). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
| 参考文献 | 1 . Patel, H. et al. (2002) Nat Genet 31, 347-8. 2 . Bakowska, J.C. et al. (2008) Arch Neurol 65, 520-4. 3 . Edwards, T.L. et al. (2009) Biochem J 423, 31-9. 4 . Lu, J. et al. (2006) J Neurochem 98, 1908-19. 5 . Eastman, S.W. et al. (2009) J Cell Biol 184, 881-94. 6 . Milewska, M. et al. (2009) J Neurochem 111, 1022-30. 7 . Lind, G.E. et al. (2011) Oncogene 30, 3967-78. |
Western blot analysis of extracts from various cell lines using Spartin Antibody.使用Spartin对多种细胞系提取物进行western blot分析。 |
