| 货号 | 5890S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SOS1 Antibody detects endogenous levels of total SOS1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Son of sevenless (SOS) was first identified in Drosophila as a guanine nucleotide exchange factor (GEF) for Ras acting downstream of the Sevenless receptor (1). Two closely related homologs of Drosophila SOS are found in mammalian cells: SOS1 and SOS2 (2). SOS1 consists of histone folds, Dbl (DH) and pleckstrin (PH) homology domains, a Ras exchange motif (REM), and Cdc25 homology and polyproline domains (3). SOS1 binds to GRB2, NCK and other adaptor proteins, and plays an important role in ERK activation downstream of protein tyrosine kinase receptor (RTK). Mutations in the corresponding SOS1 gene have been found in people with Noonan syndrome, a developmental disorder characterized by short stature, facial dysmorphia and congenital heart defects (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 152 |
| 参考文献 | 1 . Rogge, R.D. et al. (1991) Cell 64, 39-48. 2 . Nimnual, A. and Bar-Sagi, D. (2002) Sci STKE 2002, pe36. 3 . Chardin, P. et al. (1993) Science 260, 1338-43. 4 . Tartaglia, M. et al. (2007) Nat Genet 39, 75-9. 5 . Roberts, A.E. et al. (2007) Nat Genet 39, 70-4. |
Western blot analysis of extracts from various cell lines using SOS1 Antibody.Western blot方法检测细胞提取物：各种细胞系。使用的抗体是SOS1Antibody。 |
