| 货号 | 3926S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SNAP25 (D110 ) Antibody detects endogenous levels of total SNAP25 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The 25 kDa synaptosome-associated protein (SNAP25) is a target membrane soluble, N-ethylmaleimide-sensitive factor attachment protein receptor (t-SNARE) that is found on neuronal presynaptic membranes. SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis (1). This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E (2). SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD) (3). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
| 参考文献 | 1 . Salaün, C. et al. (2004) Biochim Biophys Acta 1693, 81-9. 2 . Fan, H.P. et al. (2006) J Biol Chem 281, 28174-84. 3 . Aikawa, Y. et al. (2006) Mol Biol Cell 17, 2113-24. |
Western blot analysis of extracts from mouse and rat brain using SNAP25 (D110) Antibody. Western blot分析小鼠和大鼠大脑提取物，使用的抗体是SNAP25 (D110) Antibody 兔多抗。 |
