| 货号 | 3235S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SKAR Antibody detects endogenous levels of total SKAR protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | p70 S6 kinase is a mitogen activated Ser/Thr protein kinase downstream of phosphoinositide-3 kinase (PI3K) and the target of rapamycin, FRAP/mTOR. p70 S6 kinase is required for cell growth and cell cycle progression (1,2). SKAR is a recently discovered substrate of S6K1. SKAR exists in two isoforms, α and β, the latter having a 29 amino acid truncation. Phosphorylation of SKAR is mitogen-induced and sensitive to rapamycin. Reduction in SKAR protein levels results in decreased cell size, further implicating SKAR in cell growth control (3). |
| 存放说明 | -20C |
| 计算分子量 | 46 |
| 参考文献 | 1 . Pullen, N. and Thomas, G. (1997) FEBS Lett 410, 78-82. 2 . Dufner, A. and Thomas, G. (1999) Exp Cell Res 253, 100-9. 3 . Richardson, C.J. et al. (2004) Curr Biol 14, 1540-9. |
Western blot analysis of extracts from various cell lines, using SKAR Antibody. 使用SKAR Antibody，Western blot分析不同细胞系中SKAR蛋白水平。 |
