| 货号 | 2778S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SH2D1A Antibody detects endogenous levels of total SH2D1A protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | SH2D1A and SH2D1B are small, adaptor proteins with a single SH2-domain that play important signal transduction roles mediated by the signaling lymphocytic activation molecule (SLAM) family receptors (1). SH2D1A (also called SAP or SLAM-associated protein) is frequently mutated in patients with X-linked lymphoproliferative disease (Duncan’s disease), which is characterized by extreme susceptibility to Epstein-Barr virus; approximately 50 different SH2D1A mutations have been reported to date (2-4). The single SH2D1B gene in humans (also called EAT-2 or Ewings sarcomas/FLI1-activated transcript 2) is present as a pair of duplicated EAT-2A and EAT-2B genes with identical genomic organization in mouse and rat (5,6).p>SH2D1A 和 SH2D1B 是小分子的接头蛋白， 有一个SH2域，在介导淋巴细胞的激活分子(SLAM)家族的信号受体中起了重要的信号转导作用(1)。SH2D1A (也叫做SAP或SLAM相关蛋白)在患有X-连锁的淋巴组织增生性疾病（邓肯氏病）的 病人中通常是突变的,这种疾病通常对Epstein-Barr病毒极度的敏感易感; 到目前为止报道了将近50个不同的SH2D1A 突变(2-4)。在人的基因组中有只有单个SH2D1B基因(也叫做EAT-2 或Ewings sarcomas/FLI1激活转录2)，在小鼠和大鼠基因组中此基因有一个复制即EAT-2A 和 EAT-2B基因，他们在基因组上有相同的组织方式(5,6)。 |
| 存放说明 | -20C |
| 计算分子量 | 14 |
| 参考文献 | 1 . Latour, S. and Veillette, A. (2004) Semin. Immunol. 16, 409-419. 2 . Nichols, K.E. et al. (2005) Immunol. Rev. 203, 180-199. 3 . Engel, P. et al. (2003) Nat. Rev. Immunol. 3, 813-821. 4 . Sumegi, J. et al. (2002) Leuk. Lymphoma 43, 1189-1201. 5 . Roncagalli, R. et al. (2005) Nat. Immunol. 6, 1002-1010. 6 . Calpe, S. et al. (2006) Immunogenetics 58, 15-25. |
Western blot analysis of total cell lysates from Molt4 and Jurkat cells using SH2D1A Antibody.Western免疫印迹。用SH2D1A Antibody研究Molt4和Jurkat 细胞的细胞提取液。 |
