| 货号 | 3349S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SGTA Antibody detects endogenous levels of total SGTA protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | SGTA, small glutamine-rich tetratricopeptide repeat-containing protein A, is an ubiquitously expressed co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (1,2). SGTA is a 34 kDa protein that is rich in glutamine residues at its C terminus and contains three tandemly repeated TPR motifs (3). The TPR domain of SGTA shows sequence similarity to the TPR domains of Hop, CHIP, and TOM70 (4). The TPR domain of SGTA also interacts with HSP90 and was recently found to be a pro-apoptotic factor (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 34 |
| 参考文献 | 1 . Liu, F.H. et al. (1999) J Biol Chem 274, 34425-32. 2 . Tobaben, S. et al. (2003) J Biol Chem 278, 38376-83. 3 . Cziepluch, C. et al. (1998) J Virol 72, 4149-56. 4 . Scheufler, C. et al. (2000) Cell 101, 199-210. 5 . Liou, S.T. and Wang, C. (2005) Arch Biochem Biophys 435, 253-63. 6 . Yin, H. et al. (2006) Biochem Biophys Res Commun 343, 1153-8. |
Western blot analysis of extracts from various cell lines using SGTA Antibody. 对多个细胞系使用SGTA Antibody进行Western blot分析。 | |
Western blot analysis of extracts from H1703 cells transfected with non-targeted (-) or SGTA targeted (+) siRNA. SGTA Antibody confirms the silencing of protein expression while β-Actin Antibody #4967 is used to control for loading. 对用未标记（-）或SGTA 标记 (+)的siRNA转染H1703细胞的抽提物进行Western blot分析。SGTA Antibody证实蛋白表达沉默，β-Actin Antibody #4967用作上样对照。 |
