| 货号 | 14210S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SGLT2 Antibody recognizes endogenous levels of total SGLT2 protein. This antibody does not recognize SGLT1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Na(+)/glucose cotransporter 2 (SGLT2) is one of the two main glucose transporters in the kidney proximal convoluted tubule. It is activated by Protein Kinase A and Protein Kinase C, likely through phosphorylation of Ser624 (1,2). SGLT2 is responsible for the majority of glucose reabsorption in the kidney (3,4), and mutations in SGLT2 are known to cause familial renal glucosuria (5,6). SGLT2 is a therapeutic target for type 2 diabetes. Inhibitors of SGLT2 have been developed in order to treat people with type 2 diabetes (7). |
| 存放说明 | -20C |
| 计算分子量 | 46-75 |
| 参考文献 | 1 . Feric, M. et al. (2011) Am J Physiol Cell Physiol 300, C755-70. 2 . Ghezzi, C. and Wright, E.M. (2012) Am J Physiol Cell Physiol 303, C348-54. 3 . Wells, R.G. et al. (1992) Am J Physiol 263, F459-65. 4 . Wright, E.M. (2001) Am J Physiol Renal Physiol 280, F10-8. 5 . Lee, H. et al. (2012) Pediatr Nephrol 27, 1091-5. 6 . Andrianesis, V. and Doupis, J. (2013) Expert Rev Clin Pharmacol 6, 519-39. 7 . Sheridan, C. (2012) Nat Biotechnol 30, 899-900. |
Western blot analysis of extacts from human kidney membrane fraction lysates, untreated (-) or treated with PNGase F (+), using SGLT2 Antibody. | |
Immunoprecipitation of SGLT2 from human kidney membrane extracts using Normal Rabbit IgG #2729 (lane 2) or SGLT2 Antibody (lane 3). Lane 1 is 10% input. Western blot analysis was performed using SGLT2 Antibody. |
